Begüm Topçuoğlu

Post-doctoral Research Fellow since 2018

Research areas

  • Intestinal Microbiome
  • Colorectal Cancer


  • B.S.: Sabanci University (2011)
  • Ph.D.: University of Massachusetts (2018)
Begüm Topçuoğlu


Previously, I studied the physiology of (hyper)thermophiles in hot environments such as hydrothermal vents. My work focused on how interspecies cooperation among hyperthermophilic archaea effects subseafloor life. I’m interested in understanding the changes in microbial community and physiology in an ecosystem upon perturbations and stress inducing conditions. My work in the Schloss Lab focuses on the role of host microbiome on colorectal cancer progression.

Papers from time in Schloss lab

  1. Sze MA, Topcuoglu BD, Lesniak NA, IV Ruffin MT, Schloss PD. 2019. Fecal short-chain fatty acids are not predictive of colonic tumor status and cannot be predicted based on bacterial community structure. mBio. 10: e01454-19. DOI: 10.1128/mBio.01454-19.
  2. Topcuoglu BD, Lesniak NA, Ruffin MT, Wiens J, Schloss PD. 2020. Preprint: Effective application of machine learning to microbiome-based classification problems.