Nick Lesniak

PhD Student since 2016

Research areas

  • C. difficile

Education

  • BS: University of Michigan (2014)
Nick Lesniak

Background

Papers from time in Schloss lab

  1. Tomkovich S, Lesniak NA, Li Y, Bishop L, Fitzgerald MG, Schloss PD. 2019. The proton pump inhibitor omeprazole does not promote Clostridium difficile colonization in a murine model. mSphere. 4: e00693-19. DOI: 10.1128/mSphere.00693-19.
  2. Sze MA, Topçuoğlu BD, Lesniak NA, IV Ruffin MT, Schloss PD. 2019. Fecal short-chain fatty acids are not predictive of colonic tumor status and cannot be predicted based on bacterial community structure. mBio. 10: e01454-19. DOI: 10.1128/mBio.01454-19.
  3. Baxter NT, Lesniak NA, Sinani H, Schloss PD, Koropatkin NM. 2019. The glucoamylase inhibitor acarbose has a diet-dependent and reversible effect on the murine gut microbiome. mSphere. 4: e00528-18. DOI: 10.1128/mSphere.00528-18.
  4. Topçuoğlu BD, Lesniak NA, Ruffin MT IV, Wiens J, Schloss PD. 2020. Effective application of machine learning to microbiome-based classification problems. mBio. 11: 1-13. DOI: 10.1128/mBio.00434-20.
  5. Hagan AK, Lesniak NA, Balunas MJ, Bishop L, Close WL, Doherty MD, Elmore AG, Flynn KJ, Hannigan GK, Koumpouras CC, Jenior ML, Kozik AJ, McBride K, Rifkin SB, Stough JMA, Sovacool KL, Sze MA, Tomkovich S, Topçuoğlu BD, Schloss PD. 2020. Ten simple rules to increase computational skills among biologists with Code Clubs. PLOS Computational Biology. 16: e1008119. DOI: 10.1371/journal.pcbi.1008119.
  6. Tomkovich S, Taylor A, King J, Colovas J, Bishop L, McBride K, Royzenblat S, Lesniak NA, Bergin IL, Schloss PD. 2021. An osmotic laxative renders mice susceptible to prolonged Clostridioides difficile colonization and hinders clearance. mSphere. 6: e00629-21. DOI: 10.1128/mSphere.00629-21.
  7. Lesniak NA, Schubert AM, Sinani H, Schloss PD. 2021. Clearance of Clostridioides difficile colonization is associated with antibiotic-specific bacterial changes. mSphere. 6: e01238-20. DOI: 10.1128/mSphere.01238-20.
  8. Lesniak NA, Tomkovich S, Henry A, Taylor A, Colovas J, Bishop L, McBride K, Schloss PD. 2022. Simplified fecal community transplant restores Clostridioides difficile colonization resistance to antibiotic perturbed murine communities. mBio. In press: e0136422. DOI: 10.1128/mbio.01364-22.
  9. Lesniak NA, Schubert AM, Flynn KJ, Leslie JL, Sinani H, Bergin IL, Young VB, Schloss PD. 2022. The gut bacterial community potentiates Clostridioides difficile infection severity. mBio. DOI: 10.1128/mbio.01183-22.
  10. Lapp Z, Sovacool KL, Lesniak N, King D, Barnier C, Flickinger M, Krüger J, Armour CR, Lapp MM, Tallant J, Diao R, Oneka M, Tomkovich S, Moltzau Anderson J, Lucas SK, Schloss PD. 2022. Developing and deploying an integrated workshop curriculum teaching computational skills for reproducible research. The Journal of Open Source Education. DOI: 10.21105/jose.00144.
  11. Barron MR, Sovacool KL, Abernathy-Close L, Vendrov KC, Standke AK, Bergin IL, Schloss PD, Young VB. 2022. Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis. mBio. 13: e0190422. DOI: 10.1128/mbio.01904-22.