Sarah Tomkovich
Post-doctoral Research Fellow since 2018
Research areas
- Intestinal Microbiome
- Colorectal Cancer
- Clostridium difficile infection
Education
- BS: University of Michigan (2009)
- PhD: University of North Carolina at Chapel Hill (2016)
Background
Previously, my research focused on the impact of the microbiome on host immune responses during homeostasis in zebrafish and the role of the microbiome in colorectal cancer development using mouse models. I’m interested in how the host and microbiome respond to environmental factors such as medications or diets and how these perturbations contribute to Clostridium difficile infections and colorectal cancer development.
Papers from time in Schloss lab
- Tomkovich S, Lesniak NA, Li Y, Bishop L, Fitzgerald MG, Schloss PD. 2019. The proton pump inhibitor omeprazole does not promote Clostridium difficile colonization in a murine model. mSphere. 4: e00693-19. DOI: 10.1128/mSphere.00693-19.
- Tomkovich S, Stough JMA, Bishop L, Schloss PD. 2020. The initial gut microbiota and response to antibiotic perturbation influence Clostridioides difficile colonization in mice. mSphere. 5: e00869-20. DOI: 10.1128/mSphere.00869-20.
- Hagan AK, Lesniak NA, Balunas MJ, Bishop L, Close WL, Doherty MD, Elmore AG, Flynn KJ, Hannigan GK, Koumpouras CC, Jenior ML, Kozik AJ, McBride K, Rifkin SB, Stough JMA, Sovacool KL, Sze MA, Tomkovich S, Topçuoğlu BD, Schloss PD. 2020. Ten simple rules to increase computational skills among biologists with Code Clubs. PLOS Computational Biology. 16: e1008119. DOI: 10.1371/journal.pcbi.1008119.
- Tomkovich S, Taylor A, King J, Colovas J, Bishop L, McBride K, Royzenblat S, Lesniak NA, Bergin IL, Schloss PD. 2021. An osmotic laxative renders mice susceptible to prolonged Clostridioides difficile colonization and hinders clearance. mSphere. 6: e00629-21. DOI: 10.1128/mSphere.00629-21.
- Lesniak NA, Tomkovich S, Henry A, Taylor A, Colovas J, Bishop L, McBride K, Schloss PD. 2022. Simplified fecal community transplant restores Clostridioides difficile colonization resistance to antibiotic perturbed murine communities. mBio. In press: e0136422. DOI: 10.1128/mbio.01364-22.
- Lapp Z, Sovacool KL, Lesniak N, King D, Barnier C, Flickinger M, Krüger J, Armour CR, Lapp MM, Tallant J, Diao R, Oneka M, Tomkovich S, Moltzau Anderson J, Lucas SK, Schloss PD. 2022. Developing and deploying an integrated workshop curriculum teaching computational skills for reproducible research. The Journal of Open Source Education. DOI: 10.21105/jose.00144.
- Barron MR, Sovacool KL, Abernathy-Close L, Vendrov KC, Standke AK, Bergin IL, Schloss PD, Young VB. 2022. Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis. mBio. 13: e0190422. DOI: 10.1128/mbio.01904-22.